Partial sequence conservation of SARS-CoV-2 NSP-2, NSP-12, and Spike in stool samples from Abadan, IranArticle Published on 2023-02-012023-07-08 Journal: Biotechnology and applied biochemistry [Category] COVID19(2023년), [키워드] COVID 19 Iran Phylogenetic relationship SARS coronavirus 2 spike glycoprotein viral nonstructural proteins. [DOI] 10.1002/bab.2343 PMC 바로가기
A novel statistical method predicts mutability of the genomic segments of the SARS-CoV-2 virusResearch Article Published on 2022-12-132022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] affected antiviral drugs approach candidate coding regions codon conserved correlated correlation determine develop disease distribution effective epitope Frequency genomic identify immunogenic peptide large-scale analysis mutability offer overcome pandemic pathogenesis of SARS-CoV-2 predict predicted Protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 scientist sequence Seven spike glycoprotein statistical statistical analysis target the SARS-CoV-2 virus treatments for COVID-19 Vaccine viral genome viral mutation whole genome whole genome sequence Word Ranking [DOI] 10.1017/qrd.2021.13 PMC 바로가기 [Article Type] Research Article
Omicron BA.1 and BA.2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2Article Published on 2022-12-012022-11-16 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 ACE2 receptor Affect angiotensin-converting enzyme 2 Area B.1.1.529 binding binding efficiency binding free energy conformation domain dominant explicit full-length glycans glycoprotein host cells hydrophobic interaction infect Infection initiated Interaction interactions ions Mechanics MMPBSA molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutated Mutation omicron Omicron variant performed RBD RBD-ACE2 receptor residue Salt Bridge SARS-CoV-2 SARS-CoV-2 spike glycoprotein Simulation spike spike glycoprotein spike glycoprotein. strain surface the receptor-binding domain trajectory variant variant of SARS-CoV-2 variants wild-type [DOI] 10.1016/j.jmgm.2022.108286 PMC 바로가기
Modular nanoarray vaccine for SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 변종, 진단, [키워드] B-cell epitope children complementary COVID-19 pandemic defined delta variant DNA effective epitope generate Gold nanoparticle IgG immune response immunized immunocompromised individuals immunogen immunogenic inactive mice mRNA neutralizing antibody PADRE peptide pregnant women probe recombinant proteins resulting SARS-CoV-2 spike glycoprotein time-consuming Vaccine Vaccine development vaccine platform Variants of concerns (VOC). virus neutralizing titer virus-like particles viruses VoC while wildtype [DOI] 10.1016/j.nano.2022.102604 PMC 바로가기
Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interactionArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting-enzyme-2 binding binding interaction blocking virus entry Brown caused characterized coronavirus demonstrated disease ELISA enzyme-linked immunosorbent evaluate evaluated feasible global pandemic immunization immunized Immunoglobulin immunoglobulin Y in vitro Infection inhibit kDa Laying Laying hens molecular weight Neutralizing nucleocapsid purified RBD RBD-ACE2 Receptor binding domain Receptor-binding-domain SARS-CoV-2 SARS-CoV-2. SDS-PAGE serum Specific spike glycoprotein [DOI] 10.1016/j.intimp.2022.109280 PMC 바로가기
Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Bioprocess and biosystems engineering [Category] SARS, 치료기술, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Asymptomatic binding caused combating contributed coronavirus coronavirus disease COVID-19 enzyme high affinity host receptor hydrophobic Infection Interaction lead to fatality Like molnupiravir Mutation Nanotechnology omicron pandemic pathogenic viruses PAXLOVID™ provide quercetin Remdesivir responsible SARS-CoV-2 spike glycoprotein suggested Transmissibility understanding vaccine. Vaccines viability virus [DOI] 10.1007/s00449-022-02788-8 PMC 바로가기
Sensitive Detection of SARS-CoV-2 Variants Using an Electrochemical Impedance Spectroscopy Based AptasensorArticle Published on 2022-10-282023-07-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), [키워드] aptamer aptasensor electrochemical impedance spectroscopy (EIS) SARS-CoV-2 spike glycoprotein virus. [DOI] 10.3390/ijms232113138 PMC 바로가기
Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 MPro, SPro, and RdRp: A Pharmacological PerspectiveArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] (S)-Goniothalamin Anti-viral anticancer antioxidant antiviral properties antiviral property approach characterization complex Compound coronavirus COVID-19 derivation derivative disease drug examined LC-MS molecular molecular dynamics MPro NMR pandemic performed phytochemical platform Pro RdRP required Research SARS-CoV-2 SARS-COV-2 infection Simulation study spike glycoprotein spike glycoprotein. target target protein threat [DOI] 10.3390/molecules27206962 PMC 바로가기
Quantifying Mutational Response to Track the Evolution of SARS-CoV-2 Spike Variants: Introducing a Statistical-Mechanics-Guided Machine Learning MethodArticle Published on 2022-10-132022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied Affect analysis approach average binary classification model characteristic concern Critical database defined Evolution function global public health help identify implication information interest machine learning Mutation mutations pathogenicity predict residue response SARS-CoV-2 sequence spike spike glycoprotein Stage statistical track variant virus VoC VOCs VOIs [DOI] 10.1021/acs.jpcb.2c04574 PMC 바로가기
Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants variants. Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기